GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6832769 | 1 | rs6824057 | chr4:56367278 | TMEM165 | chr4:56262090-56292342:+ | -0.14 | -3.55 | 0.000426 | Personality dimensions |
| THCA | cis | rs7692995 | 1 | rs6824748 | chr4:17997066 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.49 | 8.95E-6 | Height |
| THCA | cis | rs6825911 | 1 | rs6825911 | chr4:111381638 | ENPEP | chr4:111397229-111484491:+ | 0.17 | 4.21 | 3.11E-5 | Blood pressure |
| THCA | cis | rs2412488 | 1 | rs6827269 | chr4:54320617 | SCFD2 | chr4:53739152-54232242:- | 0.2 | 3.92 | 0.000101 | DNA methylation (variation) |
| THCA | cis | rs2273 | 1 | rs6827617 | chr4:76916146 | NAAA | chr4:76831809-76862166:- | -0.33 | -6.64 | 8.71E-11 | Longevity |
| THCA | cis | rs7692995 | 1 | rs6828122 | chr4:18006052 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.49 | 8.81E-6 | Height |
| THCA | cis | rs1061377 | 1 | rs6829234 | chr4:39116206 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.73 | 1.77E-8 | Uric acid levels |
| THCA | cis | rs1061377 | 1 | rs6829450 | chr4:39116341 | KLHL5 | chr4:39046659-39123828:+ | -0.19 | -5.41 | 1.01E-7 | Uric acid levels |
| THCA | cis | rs7692995 | 1 | rs6830062 | chr4:18017730 | DCAF16 | chr4:17802280-17812381:- | -0.19 | -4.2 | 3.2E-5 | Height |
| THCA | cis | rs7692995 | 1 | rs6831102 | chr4:18018236 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.52 | 7.89E-6 | Height |
| THCA | cis | rs683250 | 1 | rs683125 | chr11:83276245 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 3.97 | 8.36E-5 | Subcortical brain region volumes |
| THCA | cis | rs6831256 | 1 | rs6831256 | chr4:3473139 | LRPAP1 | chr4:3514290-3534224:- | 0.19 | 4.77 | 2.43E-6 | Triglycerides;Cholesterol, total;LDL cholesterol |
| THCA | cis | rs683250 | 1 | rs683250 | chr11:83276168 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.86 | 0.00013 | Subcortical brain region volumes |
| THCA | cis | rs11733284 | 1 | rs6832503 | chr4:48028442 | CNGA1 | chr4:47937996-48018610:- | -0.53 | -9.47 | 1.27E-19 | Renal underexcretion gout;Gout |
| THCA | cis | rs11733284 | 1 | rs6832503 | chr4:48028442 | FRYL | chr4:48499380-48782316:- | -0.12 | -3.66 | 0.000277 | Renal underexcretion gout;Gout |